South Park's 22nd season will premiere this Fall announces Comedy Central: NEW YORK, July 11, 2018 – Comedy Central today announced that the 22nd season of the Emmy® and Peabody® Award-winning South Park will premiere on Wednesday, September 26 at 10:00 p.m. ET/PT and also revealed that the #1 brand in comedy will be bringing two South Park activations to San Diego – Cartman’s Escape