Hyperhomocysteinemia: Impact on Neurodegenerative Diseases Dementia, Alzheimer's disease (AD), Parkinson's disease (PD) and autism are some examples of neurodegenerative diseases. International Journal of Brain Disorders and Treatment is an international, open access, peer reviewed journal that publishes articles on causes, symptoms and diagnosis of various brain disorders, infections, trauma, stroke, seizures, and tumors of brain etc.,. However, in addition to being a symptom of the underlying neurodegenerative condition, there is also emerging evidence that sleep disturbance itself may contribute to the development and facilitate the progression of several of these disorders. Sleep disturbances, stress, hypertension and high levels of alcohol consumption lead to poor brain clearance and glymphatic dysfunction and may increase the risk for developing or exacerbating neurodegenerative diseases. CiteScore: 2019: 7.8 CiteScore measures the average citations received per peer-reviewed document published in this title. Impact Factor: 6.170 ℹ Impact Factor: 2019: 6.170 The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. Arjan W. Griffioen, Patrycja Nowak-Sliwinska; Publishing model Hybrid (Transformative Journal). Journal information Editor-in-Chief. ISSN: 1756-2856 (Print) 1756-2864 (Electronic) 1756-2856 (Linking) Impact Factor. The present review will describe the chaperones network and different approaches as the therapeutic targets for neurodegenerative diseases. Another factor contributing to the observed associations may be lifestyle changes after the diagnosis of stress-related disorders, such as increased smoking and alcohol use, substance abuse, or sleep disorders, which could increase risk for neurodegenerative diseases. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. About the Journal. A number of selected high-impact full text papers will also be considered for the special journal issues. ). A recent data suggests that there is a strong inverse association between cancer and neurodegenerative disorders. Journal of Brain Disorders is an open access, peer reviewed, scholarly journal dedicated to publish novel research updates including but not limit to infections, trauma, stroke, seizures, and tumors are some of the major categories of brain diseases. Mary Sheeja T L, Dr V Gomathi, Praseeda K G. The development of new drugs for neurodegenerative disorders, very specifically to make them to reach the brain is complicated. Chin-Chan M, Navarro-Yepes J & Quintanilla-Vega B (2015) Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases… Depression is a common psychiatric disorder in the general population. 1 Many of these neurodegenerative diseases result in dementia and it is these disorders that are largely addressed in this review. In the central nervous system, microglia serve as the first line of immune defense and function in synapse pruning, injury repair, homeostasis maintenance, and regulation of brain development through scavenging and phagocytosis. Brain Research is dedicated to publishing the highest quality and greatest impact articles within the ever-evolving field of Neuroscience. ISSN: 1660-2854. For example, diffuse axonal injury is implicated in disrupting microtubule function, providing the potential context for pathologies of tau and amyloid to develop. Herbal Medicines Used for Neurodegenerative Diseases. Resultant effects of mitochondrial oxidative stress and therapeutic potential of H 2 S in neurodegenerative diseases. This allows the scientific community to view, download, distribution of an article in any medium, provided that the original work is properly cited, under the term of "Creative Commons Attribution License". As population aging is a global phenomenon, 29 age-related neurodegenerative disorders are projected to surpass cancer as the foremost cause of death after cardiovascular disease in the developed world within 20 years. Neurodegenerative diseases are disabling and fatal neurological disorders that currently lack effective treatment. 30 The late-onset sporadic form (LOAD) of Alzheimer's disease (AD) 31–33 accounts for >90% of disease cases. Neurodegenerative diseases affect millions of people worldwide. Neurodegenerative diseases represent a major threat to human health. Introduction. Neurodegenerative diseases like Parkinson’s disease (PD) and Alzheimer’s disease (AD) are considered disorders of multifactorial origin, inevitably progressive and having a long preclinical period. In many cases, patients remain undiagnosed and hence, untreated, worsening the prognosis of the neurodegenerative diseases … The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) represents a complex gene regulated cytoprotective pathway. Neurodegenerative and cerebrovascular disorders are an ever increasing, health, social and economic burden for developed Westernized countries. Journal Citation Reports (Clarivate Analytics, 2020) 5-Year Impact Factor: 6.456 ℹ Five-Year Impact Factor: 2019: 6.456 Impact Factor: 0.98* Journal of Translational Neurosciences is a peer-reviewed and an open access journal that makes significant contributions to major areas of Neurosciences. Faculty of Basic Medical Sciences, Guilin Medical University, Guilin, 541004, Guangxi, China. JNIP interfaces the disciplines of immunology, pharmacology and experimental neuroscience by acting as a platform for research discoveries into the pathogenesis and pharmacology of nervous system disorders affecting the immune system and vice versa. Therapeutic Advances in Neurological Disorders. Diseases and Disorders is an Open Access journal and we do not charge the end user when accessing a manuscript or any article. We welcome major articles and transient reports describing analysis results on microbiology, immunology, medicine, and associated disciplines, on the pathogenesis, diagnosis, and cure of infectious diseases. The 2019-2020 Journal Impact IF of Neurodegenerative Diseases is 2.418, which is just updated in 2020.. Neurodegenerative Diseases Journal Impact IF Mental Disorders and Neurodegenerative Diseases. Journal of Neurology and Neuro Toxicology (JNNT) evaluates and publishes the descriptive, analytical and experimental studies in Neurology. For starters, what is a prion disease? By enhancing communication between workers in the field throughout the world, the JIMD aims to improve the management and understanding of inherited metabolic disorders. If 'X' is the total number of articles published in 2018 and 2019, and 'Y' is the number of times these articles were cited in indexed journals during 2020 then, journal impact factor = Y/X Neurodegeneration is the progressive loss of structure or function of neurons, which may ultimately involve cell death.Many neurodegenerative diseases—such as amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, and prion diseases—occur as a result of neurodegenerative processes. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key nuclear transcription factor for the systemic antioxidant defense system. Therapeutic Advances in Neurological Disorders. New research: models, mechanisms and more In additionto the reviewcontent,this Special Collectionshowcases original research articles that impact our understanding of neurodegenerative disease mechanisms. Parkinsonism & Related Disorders is an established journal publishing the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which parkinsonism, essential tremor or related movement disorders may be a feature. Journal information Editor-in-Chief. Tissues composed primarily of … Hyperhomocysteinemia (Hhcy) is considered to be an independent risk factor for numerous pathological conditions under neurodegenerative diseases. 2010; Niu et al. It provides guidelines and reviews to the neurologists and clinicians for best practices and its outcome. Impact Factor Indicators. Subscribers receive supplements on special topics in addition to 14 regular issues of the journal … Neurodegenerative diseases represent a major threat to human health. Neurodegenerative disorders represent the most debilitating conditions, typically characterized by altered genes, elevated reactive oxygen species, mitochondrial damage, altered Ca 2+ homeostasis, atypical proteins accumulation, persistent inflammatory condition or/and neuronal damage in a specific brain area (Castelli et al., 2019; Cenini et al., 2019). Flavonoids are the most widely studied natural products for the prevention and treatment of neurodegenerative disorders. Alzheimer’s disease and Parkinson’s disease are the most common neurodegenerative diseases. Open Access — free for readers, with article processing charges (APC) paid by authors or their institutions. This review elucidates the underlying mechanism of the Nrf2-mediated neuroprotective effects on RGCs in ocular neurodegenerative diseases, such as diabetic retinopathy and retinal ischemia-reperfusion injury. Xingfeng Xu 1,2, Yan Su 1,2, Zhenyou Zou 2, Yali Zhou 1 , Jianguo Yan 1,2 . Journal of Neurology and Neuroscience (ISSN: 2171-6625) is an international circulating peer-reviewed Open Access journal presenting original research contributions and scientific advances in the field of Neurology and Neuroscience. In 2015, 46.8 million individuals worldwide had a neurodegenerative disease, with 4.6 million new cases being recorded each year. Journal of Alzheimer's Disease. Impact Factor: 2.631 ℹ Impact Factor: 2019: 2.631 The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. The 2019 (Clarivate Analytics) Impact Factor of Aging & Disease is 5.4 (5-year impact factor is 5.5) All accepted articles will be published open access. Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. ALS and related motor neuron disorders (Patten et al., 2014). There is indirect evidence to postulate Brain-derived Neurotrophic Factor (BDNF) as a potential molecular link in this association. *2020 Journal Impact Factor was established by dividing the number of articles published in 2018 and 2019 with the number of times they are cited in 2020 based on Google Scholar Citation Index database. Journal of Brain Research is a peer reviewed, open access journal considering research on all aspects of Neuroscience, Neurodegenerative diseases, Experimental neurology, Functional neurology, Traumatic Brain injury, surgical neurology, Neurological rehabilitation, Neurotoxicology, Neuropharmacology, Neuronal plasticity and Behaviour, clinical neurology, Brain … The mechanisms by which trauma can trigger neurodegeneration are increasingly understood. In this review, we discuss reciprocal interactions between malfunctioning mitochondria and lysosomes that may impact cell homeostasis and contribute to the pathophysiology of brain damage in lysosomal storage diseases. Intriguing evidences showed that COVID-19 infection can modify clinical spectrum of manifested neurological disorders but also it plays a crucial role in the development of future diseases as long-tem consequences. Sikander et al. 1. Oncology Signaling. The neuronal damage caused by these diseases may be associated with abnormal alterations of connexins in glia. Authors: Vijayaraghavan Rangachari* Many neurodegenerative pathologies such as Alzheimer's (AD), Parkinson's (PD), Huntington's (HD), Creutzfeldt Jakob diseases (CJD) etc. Dear Colleagues, The Journal of Neurological Disorders is rapidly progressing. Neurodegenerative disorders are a group of progressive neurological diseases that cause worsening motor, cognitive and autonomic dysfunction over time. The pathologies of these neurodegenerative diseases share many similarities at a subcellular level, offering the hope that a common therapy could slow the decline in multiple neurodegenerative diseases [1, 2]. Abstract. Online Journal of Neurology and Brain Disorders is an interdisciplinary open access online journal solely focusing on the loyal work in the field of Neurological and Brain Disorders. Depressive disorder and neurodegenerative diseases are two different clinical entities. Journal Citation Reports (Clarivate Analytics, 2020) 5-Year Impact Factor: 3.184 ℹ Five-Year Impact Factor: 2019: 3.184 Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI). A method, apparatus and kit have been discovered which utilize pulsed odorants, drugs, medicaments, and combinations thereof to treat diseases, symptoms of diseases and the like. Recent advances in international research, best-practice evidence, and clinical guidelines have underscored the role of physiotherapy in the management of neurodegenerative disorders. Journal of Hematology and Blood Disorders (JHBD) is a scholarly international peer-reviewed open access journal which includes a wide range of fields (Blood disorders, Anemia, Leukemia, Hematological-malignancies, etc.). Objectives Owing to a lack of data, our aim was to evaluate and compare the impact of various common neurological diseases on the risk for falls in independent community dwelling senior citizens. Alzheimer’s (AD) and Parkinson’s (PD) diseases are the most prevalent adult-onset neurodegenerative diseases worldwide, with an overall estimated annual incidence rate of 1,000–1,200 and 26.2–85.9 cases per 100,000 people, respectively (Lopez and Kuller 2019; Hirsch et al. The main objective of the journal is to disseminate the scientific work, publication, education, and exchange of ideas globally. While LAMP-2A works as a receptor for protein substrates at the lysosomal membrane, HSC70 specifically binds protein targets and takes them for CMA degradation. neurodegenerative diseases, with a focus on Alzheimer disease and synucleinopathies (ie, Parkinson disease, dementiawith Lewy bodies, multiple system atrophy), that have been better studied. Neurodegenerative diseases are considered to be chronic neurological disorders resulting from the gradual and progressive loss of nerve cells (Brown et al. Although most cases are sporadic, genes associated with familial cases have been identified, thus enabling the development of animal models. are characterized by severe changes in synaptic functions and eventual neuronal death in the brain. INTRODUCTION. Neurodegenerative diseases are neurological disorders characterized by progressive neuronal degeneration, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and Huntington's disease. The vital role of H 2 S against oxidative stress, the amplifying H 2 S level induces several molecular changes in neurodegenerative diseases by the increasing and decreasing the enzymes including CBS, CSE, and 3-3MST. Sleep changes may also serve as markers to identify patients in the preclinical stage of some neurodegenerative disorders. It covers all aspects of a range of conditions which primarily affect the neurons in the human brain. Abbreviation: Ther Adv Neurol Disord. 2. Neurodegenerative diseases are neurological disorders characterized by progressive neuronal degeneration, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and Huntington's disease. No impact factor infomation for this journal. 2005), which progressively diminishes important body activities, such as movement, coordination, breathing, balance, speech and the functioning of vital organs.There are several types of neurodegenerative diseases, … The neuronal damage caused by these diseases may be associated with abnormal alterations of connexins in glia. The diseases due to Neurodegeneration are incurable and often strike older adults and are characterized by progressive deterioration of nerve cells, eventually leading to cell death. Each of the neurodegenerative diseases has been reported to have unique pathologies and clinical features. Articles focus on the basic biology and mechanism of the disease, and medical treatment of autoimmune diseases. In this viewpoint review, we aimed to … Journal of Immunity and Infectious Diseases (JIID) is the premier international journal for original analysis on immunity and infectious diseases. Intracellular accumulations of proteins in neurons and other cells are maintained by protein degradation in proteasomes for short-lived proteins and in lysosomes for longer-lasting proteins. Setting General hospital. Abbreviation: Ther Adv Neurol Disord. Introduction. Correlation between C9ORF72 mutation and neurodegenerative diseases: A comprehensive review of the literature . One common pathway proposed to contribute to neurodegenerative diseases is mitochondrial dysfunction [3, 4]. Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive memory loss and motor impairment. Alzheimer’s and Parkinson’s spectrum disorders. Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. The Journal of Neuroimmune Pharmacology (JNIP) is the peer-reviewed journal of the Society on NeuroImmune Pharmacology. 1. Neurodegenerative Diseases and Disorders is a bimonthly journal and accepts high-quality papers in the form of either short reports or articles from a broad spectrum of scientific research areas ranging from molecular and cell biology to neuroscience, … Journal of Neurodevelopmental Disorders provides a unique venue for interdisciplinary research across the full range of neurodevelopmental disorders. Neurodegenerative diseases are collective neurological disorders that are characterized by synaptic deficiency and neuronal cell death. Hiding in Plain Sight-Could a Common Molecular Mechanism Define Neurodegenerative Diseases? Neurodegenerative diseases and aging often develop in an irreversible manner and cause a significant socioeconomic burden. As reported in Wikipedia, Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, … Faculty of Basic Medical Sciences, Guilin Medical University, Guilin, 541004, Guangxi, China. 1 Many of these neurodegenerative diseases result in dementia and it is these disorders that are largely addressed in this review. Neurodegenerative diseases are a collection of neurological diseases that are characterized by progressive loss of neurons, including AD, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) .
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